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Pricemouse3/8/2023 We guarantee delivery of at least 2 founders or 3 F1 animals for knockin. The CRISPR/Cas9 platform CB offers CRISPR-based knock-in mice at a very competitive price and complete in 3-4 months. We will provide you with a one-stop-shop from experimental design strategies to successful mouse model generation. Compared to traditional methods, the CRISPR-Cas9 system has significant advantages, including lower cost, shorter timeline and the ability to simultaneously change multiple genes.ĬRISPR/Cas9 Platform CB is a professional genetic editing biotechnology company that provides transgenic mouse models for biomedical research and drug discovery. Specific nucleotide modifications are introduced into the sequence of interest during homologous recombination. The CRISPR system can also be used due to the presence of donor DNA molecules homologous to the target region. When both sites are active, Cas9 binds to a guide RNA molecule and causes targeted double-strand breaks (DSBs) in genomic DNA. The Cas9 nuclease contains two active sites. The CRISPR/Cas9 system is a very versatile tool for a wide variety of genetic changes, including deletions, point mutations, and insertions. Therapeutic Applications of CRISPR/Cas13.Therapeutic Applications of CRISPR/Cas9.CRISPR/Cas9-Mediated Animal Disease Models.Live Imaging of the Cellular Genome via CRISPR System.CRISPR/Cas9-mediated Epigenetic Editing.CRISPR/Cas9-mediated Transcriptional Modulation.Custom CRISPRi/CRISPRa Library Services. CRISPR/Cas9 Gene Fusion Cell Line Services.Transgene-Free Genome Editing in Plants.HIEF™ Site-Specific Knock-in Cell Line Service.Reporter Gene Knockin Cell Line Generation.Conditional Knockout Cell Line Services.
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